姓名：金丹
职称：副教授
学科专业：临床检验诊断学
研究方向（招生方向）：纳米生物传感与微囊泡
办公室位置：4号楼A202
电子邮箱：jimyin_126@126.com
工作经历及任职情况
2002.07至今 湖北中医药大学检验学院临床生物化学教研室 教师
研究领域和兴趣
功能化DNA纳米探针；液体活检技术（外泌体、CTC和ctDNA）
承担课程
临床检验仪器学、临床医学检验技术、临床生物化学检验
主持或参与课题项目
1、2020/06-2023/05 一种外泌体驱动的多价DNA纳米分子机器的构建及其在肿瘤诊断和抗PD-1免疫治疗监测上的应用，主持，湖北省科技厅自然科学基金，面上类项目（2020CFB534）
2、2019/01-2020/12 构建新型外泌体检测技术用于肿瘤诊断和中药抗肿瘤研究,主持,湖北省卫健委中医药科研项目(ZY2019F032)
3、2019/8-2023/12 FET-微流控集成微系统检测胰腺癌外泌体miRNA,参与,国家自然科学基金面上项目(21974035)
4、2020/1-2023/12 气泡液体活检:用于肺癌早期预警的自聚集微气泡多功能分子界面设计、调控与集成,参与,国家自然科学基金面上项目(21974037 )
5、2018/1-2021/12 芯片式微管电极3-D微纳协同传感界面构建及用于肿瘤外泌体高效捕获与原位分析,参与,国家自然科学基金面上项目(21775034)
6、2018/1-2020/12 亚精胺在集胞藻PCC 6803抵抗氧化损伤中的分子机理研究,参与,国家自然科学基金青年项目(31700103)
7.2017/1-2018/21 DNA纳米结构介导的便携式电化学生物传感及其用于前列腺相关的microRNA高灵敏检测研究，参与，湖北省卫计委科研项目，（WJ2017Q032）
代表性论文
1. Dan Jin, Fan Yang*, Yulin Zhang, Li Liu, Yujuan Zhou,Fubing Wang, Guo-Jun Zhang*.ExoAPP: Exosome-Oriented, Aptamer Nanoprobe-Enabled Surface Proteins Profiling and Detection. Anal. Chem., 2018, 90 (24), 14402–14411.
2. Dan Jin, Xin-Xin Peng, You Qin, Peng Wu, Hao Lu, Liangchao Wang, Jing Huang, Yuting Li, Yulin Zhang, Guo-Jun Zhang*, Fan Yang*. Multivalence-Actuated DNA Nanomachines Enable Bicolor Exosomal Phenotyping and PD-L1-Guided Therapy Monitoring. Anal. Chem., 2020, 92(14), 9877-9886.
3. Dan Jin, Hao Lu,Lifei Zhu, Tongtong Guo, Xinchun Li, Xin-Xin Peng, Guoyan Mo, Lina Tang, Guo-Jun Zhang, Fan Yang*. Tumor-cell detection, labeling and phenotyping with an electron-doped bifunctional signal-amplifier. Biosens. Bioelectron., 2020, 170:112662.
4. Hui Yang, Gao Yang, Siqi Wang, Qin You, Xu Lu , Dan Jin*, Yang,Fan*,Guojun Zhang. In situ hybridization chain reaction mediated ultrasensitive enzyme-free and conjugation-free electrochemcial genosensor for BRCA-1 gene in complex matrices. Biosens. Bioelectron.，2016，80, 450-451.
5. Zhe Lu, Wei Ni, Nian Liu, DanJin, Tingxian Li, Kun Li , Yuling Zhang , Qunfeng Yao , Guo-Jun Zhang*. RISPR/Cas12a-based fluorescence biosensor for detection of exosomal miR-21 derived from lung cancer. Microchemical Journal, 2023, 187: 108370.
6. Kun Li, Jiyuan Tu, Yulin Zhang, Dan Jin, Tingxian Li, Jiahao Li, Wei Ni, Meng-Meng Xiao, Zhi-Yong Zhang, Guo-Jun Zhang*. Ultrasensitive detection of exosomal miRNA with PMO-graphene quantum dots-functionalized field-effect transistor biosensor. iScience, 2022, 25(7), 104522.
7. Feng Liang, Juan Xi , Xiangsheng Chen , Jing Huang , Dan Jin , Xiangzhi Zhu . Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis. Human & experimental toxicology 2021, 40(9), 1528-1536.
8. Xin-Xin Peng, Tongtong Guo, Hao Lu, Linlin Yue, You Li, Dan Jin, Guo-Jun Zhang, Fan Yang*. Nanostructuring Synergetic Base-Stacking Effect: An Enhanced Versatile Sandwich Sensor Enables Ultrasensitive Detection of MicroRNAs in Blood. ACS Sens. 2020, 5(8), 2514-2522.
9. Cancan Wang, Dan Jin, Yi Yu, Lina Tang, Yujie Sun, Zhongyue Sun, Guo-Jun Zhang*. A Dual Antibody-modified Nanochannel Biosensor for Capture and Identification of Exosomes. Sensors and Actuators B: Chemical. 2020, 314: 128056.
10. Chenyun Wang, Cancan Wang, Dan Jin, Yi Yu, Fan Yang, Yulin Zhang, Qunfeng Yao, and Guo-Jun Zhang*. AuNP-Amplified Surface Acoustic Wave Sensor for the Quantification of Exosomes. ACS Sens. 2020, 5( 2), 362–369.
11. Yi Yu， Yutao Li， Dan Jin， Fan Yang， Ding Wu， Mengmeng Xiao， Guojun Zhang*. Electrical and Label-Free Quantification of Exosomes with a Reduced Graphene Oxide Field Effect Transistor Biosensor. Anal. Chem., 2019, 91(16), 10679-10686.
12. Ding Wu， Hong Zhang， Dan Jin， Yi Yu， Daiwen Pang， Mengmeng Xiao，Guojun Zhang*. Microvesicle detection by a reduced graphene oxide field-effect transistor biosensor based on a membrane biotinylation strategy. Analyst, 2019，144(20), 6055-6063.
13. Huiwen Ma, Ping Wang, Dan Jin, Ting Jia, Hong Mao, Jiandi Zhang, Shi Zhao*. The hepatic ectonucleotide pyrophosphatase/phosphodiesterase 1 gene mRNA abundance is reduced by insulin and induced by dexamethasone. Brazilian Journal of Medical and Biological Research. 2018，51(4): e6980
14. Siqi Wang, Fan Yang*, Dan Jin, Guojun Zhang*. Toehold Mediated One-Step Conformation-Switchable “Signal-On” Electrochemical DNA Sensing Enhanced with Homogeneous Enzymatic Amplification.Anal. Chem., 2017, 89 (10), 5349–5356.
15. Fan Yang， Siqi Wang， Yulin Zhang， Lina Tang， Dan Jin. Toehold enabling stem-loop inspired hemiduplex probe with enhanced sensitivity and sequence-specific detection of tumor DNA in serum. Biosens. Bioelectron., 2016, 82: 32-39.
