姓名：程世博

职称：副教授

学科专业：生物分析、分析化学

研究方向：微流控技术、纳米生物分析在疾病诊断领域的应用

办公室：科技中心503

办公电话：027-68890259

电子邮箱：shibocheng@hbucm.edu.cn

教育经历：

2010.9-2014.6 武汉大学 化学与分子科学学院 本科

2014.9-2019.6 武汉大学 化学与分子科学学院 硕博连读

工作经历：

2020.1-2020.7 美国堪萨斯大学 博士后

2020.8-2024.7 美国佛罗里达大学 博士后

2024.9 至今 湖北中医药大学检验学院 副教授

研究领域和兴趣

研究方向为生物医学分析，紧密结合当前国家在生命健康领域的发展需求，旨在通过化学、工程、生物以及临床医学等多学科协同合作，开发疾病新型分子诊断技术。研究重点在于利用纳米材料、微流控技术等建立新型化学测量学方法用于蛋白，细胞外囊泡、循环肿瘤细胞等疾病标志物的分离分析，并结合机器学习方法构建诊断模型用于生命科学研究，临床疾病诊断和预后，动态治疗监测，个性化诊疗等方面。

微流控芯片技术：开发新型高效的疾病标志物分离富集技术；

纳米生物分析：基于纳米材料的疾病标志物高通量、高灵敏检测技术；

机器学习：UMAP, tSNE, logistic regression, LDA, LASSO等数据数理方法在疾病诊断模型的应用；

生物信息数据挖掘：利用生物信息学方法从数据库中挖掘疾病诊断标志物；

欢迎各位老师指导工作和洽谈研究合作！

欢迎感兴趣的同学前来课题组进行科研工作！

发表论文

1. Yi-Ru Bao, Yi-Jing Chen, Xue-Fan Deng, Yi-Ke Wang, Yu-Xin Zhang, Li-Li Xu, Wei-Hua Huang, Shi-Bo Cheng*, Hai-Bo Zhang*, Min Xie*, Boron Clusters Escort Doxorubicin Squashing into Exosomes and Overcome Drug Resistance. Advanced Science, 2024, 2412501.中科院一区 IF 14.4

2. Hao Liu¹, Qian Wang¹, Shi-Bo Cheng¹, Wei Mao, Lebao Mao, Xiuhua Zhang, Shengfu Wang, Wei-Hua Huang, Miao-Miao Chen*, ACS Sensors 2024 9 (11), 6276-6283.(Contributed equally). 中科院一区, IF 8.4

3. Jing Zhao^†, Shibo Cheng^†, Xin Wang, Ruilian Yu, Bin Du, Jiajun Tong, Yiwei Liu* and Xiaofeng Liu*. Urease-Mediated Homogeneous Dual-Mode Biosensor for On-Site Qualitative and Accurate Sensitive Quantitative Detection of Toxic Soluble Aβ Oligomers in Undiluted Serum. Revised. (Contributed equally)

4. Yu-Xin Zhang, Ming Wang, Li-Li Xu, Yi-Jing Chen, Shu-Ting Zhong, Ying Feng, Hai-Bo Zhang, * Shi-Bo Cheng,* Min Xie,* Wei-Hua Huang. An Integrated Microfluidic Chip for Synchronous Drug Loading, Separation and Detection of Plasma Exosomes. Submitted.

5. Li-Li Xu, Ming Wang, Yi-Ke Wang, Yi-Jing Chen, Yu-Xin Zhang, Yan-Qiu Zhang, Shi-Bo Cheng,* Min Xie,* Wei-Hua Huang. Vessel-like Microtunnels with Biomimetic Octopus Tentacles for Seizing and Detecting Exosomes to Diagnose Pancreatic Cancer. Submitted.

6. Yi-Ke Wang, Shi-Bo Cheng,* Min Liu, Li-Li Xu, Yi-Jing Chen, Fu-Bing Wang, Jin-Ping Zhou, Min Xie,* Wei-Hua Huang*. Efficient Capture of Circulating Tumor Cells using a Biodegradable Three-Dimensional Cellulose Scaffold for Patient-Derived Xenograft Construction. Submitted.

7. Shi-Bo Cheng, Yutao Li, He Yan, Yunjie Wen, Xin Zhou, Lee Friedman, Yong Zeng*, Recent Advances in Microfluidic Extracellular Vesicle Analysis for Cancer Diagnostics, Lab on a Chip, 2021, 21, 3219-3234.

8. Shi-Bo Cheng, Miao-Miao Chen, Yi-Ke Wang, Zi-Han Sun, Pan Cao, Wei-Guo Dong, Min Xie*, Wei-Hua Huang*. Gold Nanotubes Coated Three-Dimensional Scaffold Microchip for Effective Capture and Electrochemical Release of Circulating Tumor Cells with High Purity. Analytical Chemistry, 2021, 93 (18), 7102-7109.

9. Shi-Bo Cheng, Ming Wang, Chi Zhang, Miao-Miao Chen, Yi-Ke Wang, Shan Tian, Na Zhan, Wei-Guo Dong, Min Xie*, Wei-Hua Huang*, Flexible three-dimensional net for intravascular fishing of circulating tumor cells, Analytical chemistry, 2020, 92, 5447-5455.

10. Shi-Bo Cheng, Miao-Miao Chen, Yi-Ke Wang, Zi-Han Sun, Min Xie*, Wei-Hua Huang*. Current techniques and future advance of microfluidics devices for circulating tumor cells. TrAC Trends in Analytical Chemistry, 2019, 117, 116−127.

11. Shi-Bo Cheng, Min Xie, Yan Chen, Jun Xiong, Ya Liu, Zhen Chen, Shan Guo, Ying Shu, Ming Wang, Bi-Feng Yuan, Wei-Guo Dong*, Wei-Hua Huang*. Three-Dimensional Scaffold Chip with Thermosensitive Coating for Capture and Reversible Release of Individual and Cluster of Circulating Tumor Cells. Analytical Chemistry, 2017, 89, 7924−7932.

12. Shi-Bo Cheng, Min Xie, Jia-Quan Xu, Jing Wang, Song-Wei Lv, Shan Guo, Ying Shu, Ming Wang, Wei-Guo Dong, Wei-Hua Huang*. High-Efficiency Capture of Individual and Cluster of Circulating Tumor Cells by a Microchip Embedded with Three-Dimensional Poly(dimethylsiloxane) Scaffold. Analytical Chemistry, 2016, 88, 6773−6780.

13. Shan Tian, Shi-Bo Cheng, Ying-yun Guo, Min Xie, Na Zhan, Zhi Zeng, Wei-Hua Huang*, Wei-guo Dong*. Analysis of Tumor Cells by a Three-Dimensional Scaffold Chip for Effusions Profiling. ACS Applied Biomaterials 2020, 3 (4), 2177-2184. (Contributed equally)

授权专利：

1. 一种三维多孔微流控芯片及其制备方法与应用，黄卫华，程世博，谢敏，徐加泉，专利号：ZL 201510705017.1

2. 可逆组装和分解的荧光磁性纳米材料和纳米生物探针及其制备方法，黄卫华，谢敏，陆宁宁，庞代文，程世博，专利号：ZL2013