电子邮箱：lyt2015@hbucm.edu.cn

研究方向（招生方向）：纳米生物传感在临床检验及中医药领域的应用

工作经历及任职情况

2015.06-2018.12   湖北中医药大学检验学院   讲师

2019.03-2020.07 美国堪萨斯大学 博士后

2020.08-2021.07 美国佛罗里达大学  博士后

2019.01-2023.01    湖北中医药大学检验学院   副教授

2023.01-至 今     湖北中医药大学检验学院   教授

社会兼职

湖北省细胞外囊泡学会常务理事

湖北省中医药学会医学检验分会青年组副组长

生物医学工程传感技术学会委员

多个英文期刊杂志的审稿人

研究领域和兴趣

电化学生物传感器；活体信号分子实时监测；医学检验新方法研究

承担课程

生物化学、文献检索

主持课题项目

1、2016.01-2018.12  高性能微电极阵列传感器构建及用于神经元原位培养和实时监测研究，主持，国家自然科学基金青年项目（21505037）资助经费21万

2、2020.01-2023.12    针型场效应晶体管生物传感器的研制及其用于活体信号分子实时监测，主持，国家自然科学基金面上项目（21974036）资助经费65万

3、2016.01-2017.12  碳纳米管修饰的针灸传感针的制备及用于穴位局部五羟色胺分子的实时检测，主持， 针灸治未病协同创新中心（HBPCIC-2016-0126）资助经费4万

4、2022.01-2024.12  湖北省青年拔尖人才计划，主持，资助经费60万

5、 2023.07-2025.07 湖北省联合基金，针灸传感针的研制及用于针刺镇痛ATP 信号通路研究，主持，资助经费20万

6、2023.01-2025.12  湖北中医药大学杰出青年项目（2023ZZXJ002），电化学-荧光双功能针灸传感针用于穴位局部针刺镇痛机制研究，主持，资助经费30万

代表性论文

1、 Shanshan Yu, Yuling Pan, Lina Tang, Shimin Wu, Chunzi Liang*, Guo-Jun Zhang*, and Yu-Tao Li*. Integrated Microfluidic-Transistor Sensing System for Multiplexed Detection of Traumatic Brain Injury Biomarkers. ACS Sensor 2024, 9, 6, 3017–3026.

2、 Ling Xiao, Shanshan Yu, Qing Cui, Jiacheng Liu, Guowu Liang, Yutao Li*, GuoJun Zhang*.Phthalocyanine-functionalized ffeld-effect transistor biosensor for in situ monitoring of cell-released hydrogen sulffde. Sensors & Actuators: B. Chemical 2024, 406, 135402.

3、 Tingxian Li, Lina Tang, Kun Li, Binzhu Liu, Meng-Meng Xiao, Nian Liu, Wei Ni, Yutao Li*, Zhiyong Zhang*, Guo-Jun Zhang*. Functionalized carbon nanotube field-effect transistor biosensor for highly sensitive detection of exosomal protein. Analytica Chimica Acta 2023, 1273, 341511.

4、 Binzhu Liu, Shanshan Yu, Ying Zhou, Yongmin Lei, Lina Tang, Guo-Jun Zhang*and Yu-Tao Li*. A Dual-Needle Field-Effect Transistor Biosensor for in-Vivo pH Monitoring. ACS Sensor 2023, 8, 2609-2617.

5、 Ying Zhou, Binzhu Liu, Yongmin Lei, Lina Tang, Tingxian Li, Shanshan Yu, Guo-Jun Zhang*, Yu-Tao Li*. Acupuncture Needle ‐Based Transistor Neuroprobe for In Vivo Monitoring of Neurotransmitter. Small 2022, 2204142, DOI: 10.1002/smll.202204142.

6、 Ling Xiao, Kun Li, Binzhu Liu, Jiyuan Tu, Tingxian Li, Yu-Tao Li* and Guo-Jun Zhang*. A pH-sensitive field-effect transistor for monitoring of cancer cell external acid environment. Talanta, 2023, (252) 123764. （共通讯）

7、 Ying Zhou, Fan Ding, Guo-Jun Zhang, Li-Na Tang*, Yu-Tao Li*. Micro-needle electrode for real-time monitoring of norepinephrine in rat central nervous system. Chinese J. Anal. Chem. 2021, 49, 35–40.

8、 Mengke Yu^#, Yu-Tao Li^#, Youfan Hu, Lina Tang, Fan Yang, Wen-Liang Lv, Zhi-Yong Zhang, Guo-Jun Zhang, Gold nanostructure-programmed flexible electrochemical biosensor for detection of glucose and lactate in sweat, Journal of Electroanalytical Chemistry, 2021, 882, 115029.（共一作）

9、 Yu-Tao Li, Xin Jin, Lina Tang, Wen-Liang Lv, Meng-Meng Xiao, Zhi-Yong Zhang, Chuan Gao*, Guo-Jun Zhang*. Receptor-Mediated Field Effect Transistor Biosensor for Real-Time Monitoring of Glutamate Release from Primary Hippocampal Neurons. Anal. Chem. 2019, 91(13), 8229-8236. DOI: 10.1021/acs.analchem.9b00832.

10、 Chao Zheng, Xin Jin, Yutao Li*, Junchi Mei, Yujie Sun, Mengmeng Xiao, Hong Zhang, Zhiyong Zhang* & Guo-Jun Zhang*. Sensitive Molybdenum Disulfide Based Field Effect Transistor Sensor for Real-time Monitoring of Hydrogen Peroxide. Sci. Rep. 2019（759）. DOI : 10.1038/s41598-018-36752-y（共通讯）

11、 Jin-Xiu Zhou, Fan Ding, Li-Na Tang, Teng Li, Yun-Hui Li, Yu-Jie Zhang, Hao-Yue Gong, Yu-Tao Li* and Guo-Jun Zhang*. Monitoring of pH changes in a live rat brain with MoS2/PAN functionalized microneedles. Analyst, 2018,143, 4469-4475（共通讯）

12、 Lina Tang#, Yu-Tao Li#, Hui Xie, Qing Shu, FanYang, Yan-ling Liu, Feng-Xia Liang, Hua Wang Weihua Huang* & Guo-Jun Zhang*. A sensitive acupuncture needle microsensor for real-time monitoring of nitric oxide in acupoints of rats. Sci. Rep. 2017, 7: 6446, DOI: 10.1038/s41598-017-06657-3（共一作）.

13、 Jin-Xiu Zhou, Li-Na Tang, Fan Yang, Feng-Xia Liang, Hua Wang, Yu-Tao Li* and Guo-Jun Zhang*. MoS2/Pt nanocomposites functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cell. Analyst, 2017,142, 4322-4329.（共通讯）

14、 Hui Xie#, Yu-Tao Li#, Yong-Min Lei,Yan-Ling Liu, Meng-Meng Xiao, Chuan Gao, Dai-Wen Pang, Wei-Hua Huang*,  Zhi-Yong Zhang*, and Guo-Jun Zhang*. Real-Time Monitoring of Nitric Oxide at Single-Cell Level with Porphyrin-Functionalized Graphene Field-Effect Transistor Biosensor. Anal. Chem. 2016,88 (22), 11115-11122 DOI: 10.1021/acs.analchem.6b03208（共一作）

15、 Yu-Tao Li, Li-Na Tang, Yong Ning, Qing Shu, Feng-Xia Liang, Hua Wang &Guo-Jun Zhang*. In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle. Sci. Rep. 2016, 6:28018, DOI: 10.1038/srep28018.

16、 Yu-Tao Li, Shu-Hui Zhang, Xue-Ying Wang, Xin-Wei Zhang, Alexander I. Oleinick, Irina Svir, Christian Amatore,* and Wei-Hua Huang*. Real-time Monitoring of Discrete Synaptic Release Events and Excitatory Potentials within Self-reconstructed Neuromuscular Junctions. Angew. Chem. Int. Ed., 2015, 54(32), 9313-9318. （hot paper）.

17、 Yu-Tao Li, Shu-Hui Zhang, Li Wang, Rong-Rong Xiao, Wei Liu, Xin-Wei Zhang, Zhuan Zhou, Christian Amatore and Wei-Hua Huang*. Nanoelectrode for Amperometric Monitoring of Individual Vesicular Exocytosis inside Single Synapses. Angew. Chem. Int. Ed., 2014, 53(46), 12456-12460.