研究领域和兴趣：

稀土荧光纳米探针；核酸适配体；疾病标志物检测

学习工作经历：

2012.09-2016.06  武汉大学 化学与分子科学学院化学基地班   学士

2016.09-2021.06  武汉大学 化学与分子科学学院分析化学专业  博士

2021.07-2024.08  武汉市农业科学院                     助理研究员

2024.09至今  湖北中医药大学 检验学院      副教授

代表性论文：

1. Zhihao Li#, Huajian Gao#, Ruichen Shen#, Caixin Zhang, Leisi Li, Yawei Lv, Liming Tang, Yaping Du, Quan Yuan*. Facet selectivity guided assembly of nanoarchitectures onto two-dimensional metal-organic framework nanosheets. Angewandte Chemie International Edition, 2021, 60, 17564-17569. (影响因子16.6，中科院一区)

2. Zhihao Li#, Haoran Liu#, Rui Wang#, Chenhui Ji, Yan Wei, Miusi Shi, Yingqian Wang, Yaping Du, Yufeng Zhang*, Quan Yuan*, Chunhua Yan. Bioactive core-shell CaF2 upconversion nanostructure for promotion and visualization of engineered bone reconstruction. ACS Nano, 2020, 14, 16085-16095. (影响因子17.1，中科院一区)

3. Zhihao Li, Jiao Hu, Yifang Zhan, Zhiyong Shao, Mengyue Gao, Qi Yao, Zheng Li, Shaowen Sun, Lihua Wang*. Coupling bifunctional nanozyme-mediated catalytic signal amplification and label-free SERS with immunoassays for ultrasensitive detection of pathogens in milk samples. Analytical Chemistry, 2023, 95, 6417-6424. (影响因子7.4，中科院一区)

4. Zhihao Li, Xue Li, Qiaosong Lin, Yifang Zhan, Jiao Hu, Taohong Zhou, Mengyue Gao, Ting He, Qi Yao, Lihua Wang*. Interfacial engineering of two-dimensional metal-organic framework nanozyme to enhance substrate affinity for the rapid and highly sensitive detection of Cr(VI). Sensors & Actuators: B. Chemical, 2024, 418, 136341. (影响因子8.4，中科院一区)

5. Lihua Wang, Zhiheng Li, Yingqian Wang, Mengyue Gao, Ting He, Yifang Zhan*, Zhihao Li*. Surface ligand-assisted synthesis and biomedical applications of metal-organic framework nanocomposites. Nanoscale, 2023, 15, 10529. (通讯作者，影响因子6.7，中科院二区)

6. Wenjing Dai, Bing Qi, Zhihao Li*, Jie Wang*. Bimodal persistent luminescence for autofluorescence-free ratiometric biosensing. Analytical and Bioanalytical Chemistry, 2023, 415, 6723-6731. (通讯作者，影响因子4.3，中科院二区)

7. Haoran Liu#, Zhihao Li# , Ruichen Shen, Zhiheng Li, Yanbing Yang*, Quan Yuan*. Point-of-care pathogen testing using photonic crystals and machine vision for diagnosis of urinary infections. Nano Letters, 2021, 21, 2854-2860. (共同一作，影响因子10.8，中科院一区)

8. Qiaosong Lin#, Zhihao Li#, Chenhui Ji, Quan Yuan*. Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles. Nanoscale Advances, 2020, 2, 1380. (共同一作，影响因子4.7，中科院三区)

9. Yingqian Wang#, Zhihao Li#, Qiaosong Lin, Yurong Wei, Yingxue Li, Ronghua Yang, Quan Yuan*. Highly sensitive detection of bladder cancer-related miRNA in urine using time-gated luminescent biochip. ACS Sensors, 2019, 4, 2124-2130. (共同一作，影响因子8.9，中科院一区)

10. Zhihao Li, Jie Wang, Yingxue Li, Xinwen Liu, Quan Yuan*. Self-assembled DNA nanomaterials with highly programmed structures and functions. Materials Chemistry Frontiers, 2018, 2, 423. (影响因子7.0，中科院二区)

11. Zhihao Li, Xiangdong Yang, Yanbing Yang, Yaning Tan, Yue He, Meng Liu, Xinwen Liu, Quan Yuan*. Peroxidase-mimicking nanozyme with enhanced activity and high stability based on metal-support interactions. Chemistry – A European Journal, 2018, 24, 409-415. (影响因子4.3，中科院二区)

项目承担情况:

1. 湖北省自然科学基金青年项目（2022.06-2024.06），5万，主持